Important paper by Martin Pall published in 'The Townsend Letter'
Multiple Chemical Sensitivity researcher Martin L. Pall’s paper, 'How can we cure NO/ONOO− cycle diseases? Approaches to curing chronic fatigue syndrome/Myalgic Encephalomyelitis, fibromyalgia, multiple chemical sensitivity, gulf war syndrome and possibly many others', is published in the February/March 2010 issue of The Townsend Letter: The Examiner of Alternative Medicine. More details here.
The entire essay is published at the Townsend, here’s an excerpt:
This paper argues that what is called the central couplet of the cycle, the reciprocal relation between peroxynitrite elevation and BH4 depletion, is not being adequately downregulated by these multiagent protocols. Ten agents/classes of agents are available, each of which downregulates one or the other end of this central couplet. It is suggested, then, that treatments that simultaneously effectively downregulate both ends to the central couplet, when used along with multiagent protocols lowering other aspects of the cycle and avoidance of stressors that otherwise upregulate the cycle, will lead to substantial numbers of cures of these chronic diseases.
A major paper on Multiple Chemical Sensitivity by Pall was published last year as chapter XX in a prestigious reference work for professional toxicologists, General and Applied Toxicology, 3rd Edition (2009, John Wiley & Sons). Pall’s paper, entitled 'Multiple Chemical Sensitivity: Toxicological Questions and Mechanisms', establishes five important facts about MCS:
1) MCS is common;
2) MCS is caused by toxic chemical exposure;
3) the role of chemicals acting as toxicants in MCS has been confirmed by genetic studies;
4) there is a detailed and generally well supported mechanism for MCS, the NO/ONOO- cycle; and
5) MCS is a physiological disease initiated by toxic chemical exposure that has been falsely claimed to be psychogenic.
Pall is located in the US (Pacific time) and can be contacted at: 503-232-3883 and at martin_pall@wsu.edu. His web site is thetenthparadigm.org.
Source: The Canary Report, February 25th 2010.
